Event Details


Registration Not Required

Neuroscience Graduate Seminar Series Lecture: "The Neuroscience of Major Depression: Focus on Anhedonia"

Date: October 18, 2017

Time: 4:10PM to 5:10PM

Location: 1220 MRB III Lecture Hall

Event Flyer: Pizzagalli flyer.pdf


The Neuroscience of Major Depression: Focus on Anhedonia

Diego Pizzagalli, Ph.D., Director, Center for Depression, Anxiety and Stress Research; Director, McLean Imaging Center; Director, Laboratory for Affective and Translational Neuroscience; Professor, Department of Psychiatry, Harvard Medical School

Wednesday, Oct. 18, 2017, 4:10-5:10 p.m.
1220 MRB III Lecture Hall

Anhedonia - the loss of pleasure or lack of reactivity to pleasurable stimuli - is a core symptom of depression and a potential risk factor for various forms of psychopathology. Few studies have employed laboratory-based measures to objectively characterize this important depressive phenotype. Further, although preclinical data have emphasized stress-mediated disturbances of mesocorticolimbic dopaminergic functions in the pathophysiology of depression, the mechanisms underlying these processes are largely unknown in humans. Findings from recent studies in Dr. Pizzagalli's laboratory combining behavioral, functional neuroimaging, and molecular imaging approaches to study the neurobiology of anhedonia will be reviewed. Collectively, these findings indicate that depression is characterized by an impaired tendency to modulate behavior as a function of prior reinforcements and dysfunction in brain reward pathways. The potential role of stressors and dopamine in depression will be discussed.

Co-sponsor Vanderbilt Brain Institute

No registration is necessary.

For more information, contact (615) 322-8240.

The VKC welcomes persons with disabilities.

Contact kc@vanderbilt.edu or 615-322-8240 for disability access information; 2 weeks advance notice is recommended for some accommodations (e.g., Braille, signing).