The Neuroscience of Major Depression: Focus on Anhedonia
Diego Pizzagalli, Ph.D., Director, Center for Depression, Anxiety and Stress Research; Director, McLean Imaging Center; Director, Laboratory for Affective and Translational Neuroscience; Professor, Department of Psychiatry, Harvard Medical School
Wednesday, Oct. 18, 2017, 4:10-5:10 p.m.
1220 MRB III Lecture Hall
Anhedonia - the loss of pleasure or lack of reactivity to pleasurable stimuli - is a core symptom of depression and a potential risk factor for various forms of psychopathology. Few studies have employed laboratory-based measures to objectively characterize this important depressive phenotype. Further, although preclinical data have emphasized stress-mediated disturbances of mesocorticolimbic dopaminergic functions in the pathophysiology of depression, the mechanisms underlying these processes are largely unknown in humans. Findings from recent studies in Dr. Pizzagalli's laboratory combining behavioral, functional neuroimaging, and molecular imaging approaches to study the neurobiology of anhedonia will be reviewed. Collectively, these findings indicate that depression is characterized by an impaired tendency to modulate behavior as a function of prior reinforcements and dysfunction in brain reward pathways. The potential role of stressors and dopamine in depression will be discussed.
Co-sponsor Vanderbilt Brain Institute
No registration is necessary.
For more information, contact (615) 322-8240.