Overview of Interests
Brain function depends on the creation and maintenance of neural circuits with precisely defined patterns of connectivity. We use the nematode, C. elegans, a model organism with a simple nervous system and powerful genetic tools to identify molecules that govern these events. Our work exploits a comprehensive wiring diagram that defines the anatomy and connectivity all 302 neurons in the C. elegans nervous system. We use a combination of mutant analysis and neuron-specific expression profiling to reveal genes that define the architecture of this network.
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- A Novel Strategy to Identify ARX Target Genes With Key Roles in Brain Development (Nicholas Hobbs Discovery Grant)
- Molecular Genetics of Synaptic Plasticity
- Molecular Regulation of Dendrite Morphogenesis
- Molelcular Determinants of Synaptic Plasticity
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